Bodyweight is controlled through a number of different factors, and therefore weight loss is most efficiently approached by targeting multiple pathways. For example, stimulating AMPK will regulate metabolic function, activating BAT will stimulate thermogenesis, targeting thyroid hormone will increase energy expenditure, and PPAR activation will increase metabolism and inhibit adipogenesis.
What is AMPK?
AMP-activated protein kinase (AMPK) is responsible for the regulation of metabolic function. During periods of energy stress such as exercise, AMPK is activated, stimulating energy-generating processes such as glucose uptake and fatty acid oxidation for ATP production. It will also decrease functions that require ATP, such as lipid synthesis.
What is BAT?
Brown adipose tissue (BAT) is responsible for thermogenesis, caused by the stimulation of intracellular lipolysis Is is normally activated by the sympathetic nervous system in order to regulate body temperature, but can also be stimulated by high-calorie diets and certain nutrients. BAT also plays a role in insulin sensitivity.
What is thyroid hormone?
The thyroid is a butterfly-shaped endocrine gland located at the base of your neck. The thyroid influence processes such as the basal metabolic rate, carbohydrate, and lipid metabolism, and protein synthesis through the production and release of two thyroid hormones triiodothyronine (T 3 ) and thyroxine(T 4 ), which is regulated by thyroid-stimulating hormone (TSH), which comes from the pituitary gland.
What is PPAR?
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of the nuclear hormone receptor superfamily. There are three subtypes: PPARα, PPARγ, and PPARβ/δ. Activation of PPAR-α reduces triglyceride levels and is involved in the regulation of energy homeostasis. Activation of PPAR-γ causes insulin sensitization and enhances glucose metabolism, whereas activation of PPAR-β/δ enhances fatty acids metabolism.
GNIT3 contains 9 powerful ingredients to target fat burning through multiple pathways! Gynostemma pentaphyllum leaf extract will activate AMPK to stimulate fat oxidation and glucose uptake, and can potentially reduce blood glucose levels.
Olive leaf extract is a versatile ingredient that activates BAT as well as acts upon the PPAR-γ receptor. Our olive leaf extract is standardized for oleuropein that has antioxidant, anti-inflammatory, and anti-atherogenic effects, as well as suppresses proliferation of fat cells in the body. Oleuropein inhibits PPAR-γ to exert anti-adipogenic effects, as well as enhances thermogenesis by increasing uncoupling
protein 1 (UCP1) in interscapular BAT and urinary noradrenaline and adrenaline secretions. Caffeine is a stimulant that increases lipolysis, breaking down fat, and decreasing fat storage. It also helps with appetite suppression and is a mild diuretic. Finally, it helps with energy, focus, and reduction of fatigue.
Aframomum melegueta, also known as grains of paradise, stimulates BAT to increase energy expenditure and stimulate diet-induced thermogenesis.
Sesamol is an antioxidant and anti-inflammatory ingredient that has antimutagenic properties and is an efficient scavenger of reactive oxygen species. It also is a PPAR-γ modulator and helps to improve insulin resistance, hyperinsulinemia, hyperglycemia, and dyslipidemia. Tangerine seed extract supports fat loss and acts as a glucose disposal agent. Teacrine® is a patented form of theacrine. It increases energy, focus, and endurance, as well as improves mood. Unlike many stimulants, it is non-habituating and has no tolerance build up or desensitization. It is longer acting than caffeine and does not have an energy crash. Ginger root extract is standardized for gingerols, which activate PPAR-δ to improve weight loss by increasing energy expenditure and “browning” white fat, in turn reducing body weight, glucose levels, leptin, insulin, and lipids. Dynamine® is a patented form of N-methyliberine. It is a fast-acting and powerful stimulant that provides smooth energy and enhanced mood, focus, and motivation. The combination of caffeine,
Teacrine®, and Dynamine® provides both immediate and long-lasting energy, focus, and alertness.